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When Jennifer Doudna was a sixth grader in Hilo, Hawaii, she came home from school one afternoon and found a book on her bed. It was The Double Helix, James Watson’s account of how he and Francis Crick had discovered the structure of DNA, the spiral-staircase molecule that carries the genetic instruction code for all forms of life. This book guided Jennifer Doudna to focus her studies not on DNA, but on what seemed to take a backseat in biochemistry: figuring out the structure of RNA, a closely related molecule that enables the genetic instructions coded in DNA to express themselves.

The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity - by chewing, brewing, and snorting - some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the 5,000-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze Age medicine, a worm-killing birch fungus, knotted to his leggings.

The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic medication. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.

Levitt and co-author Stephen J. Dubner show that economics is, at root, the study of incentives: how people get what they want, or need, especially when other people want or need the same thing. In Freakonomics, they explore the hidden side of...well, everything. The inner working of a crack gang...the truth about real-estate agents...the secrets of the Klu Klux Klan. What unites all these stories is a belief that the modern world is even more intriguing than we think. All it takes is a new way of looking, and Freakonomics will redefine the way we view the modern world.

From 1942 through 1972, American biomedical researchers deliberately infected people with hepatitis. Government-sponsored researchers were attempting to discover the basic features of the disease and the viruses causing it, and to develop interventions that would quell recurring outbreaks. Drawing from extensive archival research and in-person interviews, Sydney Halpern traces the hepatitis program from its origins in World War II through its expansion during the initial Cold War years, to its demise in the early 1970s amid an outcry over research abuse.

Vaccine reluctance and refusal are no longer limited to the margins of society. Debates around vaccines' necessity - along with questions around their side effects - have gone mainstream, blending with geopolitical conflicts, political campaigns, celebrity causes, and "natural" lifestyles to win a growing number of hearts and minds. Today's anti-vaccine positions find audiences where they've never existed previously.

Company of Women is based on the exploits of one of America’s most entrepreneurial minds at the time of the 1904 World’s Fair in St. Louis. B promoting a woman’s right to vote, Edward Garner Lewis built a women’s magazine empire that spanned the country until a conspiracy–all the way up to President Teddy Roosevelt–threatened to destroy it all.

With The Glass Ledge, Oubou offers a disruptive guide that explores the 10 most common themes around which women tend to derail themselves, including issues around power, likability, authenticity, conflict, and more. They are organized according to when we are most likely to face them head-on, as some issues present earlier in our careers while others tend to appear later. Each chapter focuses on one of these nuanced themes, incorporating counterintuitive and eye-opening information, including:

The 19th century was an exciting time of initiative and enterprise around the world. If John D. Rockefeller was creating unimagined wealth in the United States that he would put to the service of the nation, a Parsi family with humble roots was doing the same in India. The Tatas is a tribute to a line of visionaries who have a special place in the hearts and minds of ordinary Indians. Written by seasoned journalist Girish Kuber, this is also the only book that tells the complete Tata story spanning almost 200 years.

Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells - taken without her knowledge - became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than 60 years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects.

Are leaders born or made? Where does ambition come from? How does adversity affect the growth of leadership? Does the man make the times or do the times make the man? In Leadership, Goodwin draws upon four of the presidents she has studied most closely - Abraham Lincoln, Theodore Roosevelt, Franklin D. Roosevelt, and Lyndon B. Johnson (in civil rights) - to show how they first recognized leadership qualities within themselves, and were recognized by others as leaders.

Napoleon Hill’s all-time classic of successful living is a must-hear—and lifetime companion—for anyone who wants to break away from depleting fears, limiting patterns, and unfinished plans to step into a life of dynamism, achievement, and true prosperity. This special edition of Think and Grow Rich features Hill’s complete 1937 text and the definitive introduction to the teacher’s career and methods by popular voice of esotericism Mitch Horowitz.

Full of unforgettable figures and an unrelenting spirit of adventure, Strange Stones is a far-ranging, thought-provoking collection of Peter Hessler’s best reportage - a dazzling display of the powerful storytelling, shrewd cultural insight, and warm sense of humor that are the trademarks of his work. Over the last decade, as a staff writer for The New Yorker and the author of three books, Peter Hessler has lived in Asia and the United States, writing as both native and knowledgeable outsider in these two very different regions.

It is 1919 and Elizabeth Hughes, the 11-year-old daughter of America's most-distinguished jurist and politician, Charles Evans Hughes, has been diagnosed with juvenile diabetes. It is essentially a death sentence. The only accepted form of treatment - starvation - whittles her down to 45 pounds, skin and bones. Miles away, Canadian researchers Frederick Banting and Charles Best manage to identify and purify insulin from animal pancreases - a miracle soon marred by scientific jealousy, intense business competition, and fistfights.

When Janey Sweet, CEO of a couture wedding dress company, is photographed in the front row of a fashion show eating a bruffin - the delicious lovechild of a brioche and a muffin - her best friend and business partner, Beau, gives her an ultimatum: lose 30 pounds or lose your job. Sure, Janey has gained some weight since her divorce, and no, her beautifully cut trousers don't fit like they used to, so Janey throws herself headlong into the world of the fitness revolution.

From trips on private jets and encounters with world leaders to shocking accounts of misogyny and double standards behind the scenes, this searing memoir exposes both the personal and the political fallout when unfettered power and a rotten company culture take hold. In a gripping and often absurd narrative where a few people carelessly hold the world in their hands, this eye-opening memoir reveals what really goes on among the global elite.

When Elon Musk was a kid in South Africa, he was regularly beaten by bullies. One day a group pushed him down some concrete steps and kicked him until his face was a swollen ball of flesh. He was in the hospital for a week. But the physical scars were minor compared to the emotional ones inflicted by his father, an engineer, rogue, and charismatic fantasist.

Based on more than 40 interviews with Jobs conducted over two years—as well as interviews with more than a hundred family members, friends, adversaries, competitors, and colleagues—Walter Isaacson has written a riveting story of the roller-coaster life and searingly intense personality of a creative entrepreneur whose passion for perfection and ferocious drive revolutionized six industries: personal computers, animated movies, music, phones, tablet computing, and digital publishing.

Why we think it’s a great listen: You thought he was a stodgy scientist with funny hair, but Isaacson and Hermann reveal an eloquent, intense, and selfless human being who not only shaped science with his theories, but politics and world events in the 20th century as well. Based on the newly released personal letters of Albert Einstein, Walter Isaacson explores how an imaginative, impertinent patent clerk became the mind reader of the creator of the cosmos.

Reporter Sam Kean reveals the periodic table as it’s never been seen before. Not only is it one of man's crowning scientific achievements, it's also a treasure trove of stories of passion, adventure, betrayal, and obsession. The infectious tales and astounding details in The Disappearing Spoon follow carbon, neon, silicon, and gold as they play out their parts in human history, finance, mythology, war, the arts, poison, and the lives of the (frequently) mad scientists who discovered them.

Naval Ravikant is an entrepreneur, philosopher, and investor who has captivated the world with his principles for building wealth and creating long-term happiness. The Almanack of Naval Ravikant is a collection of Naval’s wisdom and experience from the last 10 years, shared as a curation of his most insightful interviews and poignant reflections. This isn’t a how-to book, or a step-by-step gimmick. Instead, through Naval’s own words, you will learn how to walk your own unique path toward a happier, wealthier life.

When Michael Pollan set out to research how LSD and psilocybin (the active ingredient in magic mushrooms) are being used to provide relief to people suffering from difficult-to-treat conditions such as depression, addiction, and anxiety, he did not intend to write what is undoubtedly his most personal book. But upon discovering how these remarkable substances are improving the lives not only of the mentally ill but also of healthy people coming to grips with the challenges of everyday life, he decided to explore the landscape of the mind in the first person as well as the third.

J. Robert Oppenheimer was one of the iconic figures of the 20th century, a brilliant physicist who led the effort to build the atomic bomb but later confronted the moral consequences of scientific progress. When he proposed international controls over atomic materials, opposed the development of the hydrogen bomb, and criticized plans for a nuclear war, his ideas were anathema to powerful advocates of a massive nuclear buildup during the anti-Communist hysteria of the early 1950s.

Suzanne Simard is a pioneer on the frontier of plant communication and intelligence; her TED talks have been viewed by more than 10 million people worldwide. In this, her first book, now available in audio, Simard brings us into her world, the intimate world of the trees, in which she brilliantly illuminates the fascinating and vital truths—that trees are not simply the source of timber or pulp, but are a complicated, interdependent circle of life.

From the New York Times bestselling author of Midnight in Chernobyl comes the definitive, dramatic, minute-by-minute story of the Challenger disaster, based on fascinating in-depth reporting and new archival research—a riveting history that flows like a thriller.

The bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.

Two-time winner of the Pulitzer Prize David McCullough tells the dramatic story behind the story about the courageous brothers who taught the world how to fly: Wilbur and Orville Wright.

On December 17, 1903, at Kitty Hawk, North Carolina, Wilbur and Orville Wright's Wright Flyer became the first powered, heavier-than-air machine to achieve controlled, sustained flight with a pilot aboard. The Age of Flight had begun. How did they do it? And why?

As Wall Street swooned and boomed through the last decade, our livelihoods have—now more than ever—come to rely upon the good sense and risk appetites of a few standout investors. And amidst the BlackRocks, Vanguards, and Berkshire Hathaways stands arguably the most iconoclastic of them all: SoftBank’s Masayoshi Son. In Gambling Man, the first Western biography of Son, the self-professed unicorn hunter, we go behind the scenes of the world’s most monied halls of power in New York, Tokyo, Silicon Valley, Saudi Arabia, and beyond.

In 2007 and 2008, Time named Paul Allen, the cofounder of Microsoft, one of the 100 most influential people in the world. Since he made his fortune, his impact has been felt in science, technology, business, medicine, sports, music, and philanthropy. His passion, curiosity, and intellectual rigor - combined with the resources to launch and support new initiatives - have literally changed the world. With honesty, humor, and insight, Allen here tells the story of a life of ideas made real.

In Thunderstruck, Erik Larson tells the interwoven stories of two men: Hawley Crippen, a very unlikely murderer, and Guglielmo Marconi, the obsessive creator of a seemingly supernatural means of communication. Their lives intersect during one of the greatest criminal chases of all time.

When Randy Pausch, a computer science professor at Carnegie Mellon, was asked to give such a lecture, he didn't have to imagine it as his last, since he had recently been diagnosed with terminal cancer. But the lecture he gave - "Really Achieving Your Childhood Dreams" - wasn't about dying. It was about the importance of overcoming obstacles, of enabling the dreams of others, of seizing every moment (because "time is all you have... and you may find one day that you have less than you think").

Astrophysicist Neil deGrasse Tyson has attracted one of the world’s largest online followings with his fascinating, widely accessible insights into science and our universe. Now, Tyson invites us to go behind the scenes of his public fame by unveiling his candid correspondence with people across the globe who have sought him out in search of answers. In this hand-picked collection of 100 letters, Tyson draws upon cosmic perspectives to address a vast array of questions about science, faith, philosophy, life, and of course, Pluto.

Don and Mimi Galvin seemed to be living the American dream. After World War II, Don's work with the Air Force brought them to Colorado, where their 12 children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins—aspiration, hard work, upward mobility, domestic harmony. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the 10 Galvin boys, one after another, were diagnosed as schizophrenic.

With his characteristic eyebrow-raising behavior, Richard P. Feynman once provoked the wife of a Princeton dean to remark, "Surely you're joking, Mr. Feynman!" But the many scientific and personal achievements of this Nobel Prize-winning physicist are no laughing matter. Here, woven with his scintillating views on modern science, Feynman relates the defining moments of his accomplished life.

Dame Sue Black is an internationally renowned forensic anthropologist and human anatomist. She has lived her life eye to eye with the Grim Reaper, and she writes vividly about it in this book, which is part primer on the basics of identifying human remains, part frank memoir of a woman whose first paying job as a schoolgirl was to apprentice in a butcher shop, and part no-nonsense but deeply humane introduction to the reality of death in our lives. It is a treat for CSI junkies, murder mystery and thriller fans, and anyone seeking a clear-eyed guide to a subject that touches us all.

Before John Glenn orbited the Earth or Neil Armstrong walked on the moon, a group of dedicated female mathematicians known as "human computers" used pencils, slide rules, and adding machines to calculate the numbers that would launch rockets and astronauts into space. Among these problem solvers were a group of exceptionally talented African American women, some of the brightest minds of their generation.