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The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity - by chewing, brewing, and snorting - some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the 5,000-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze Age medicine, a worm-killing birch fungus, knotted to his leggings.

The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic medication. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.

When Jennifer Doudna was a sixth grader in Hilo, Hawaii, she came home from school one afternoon and found a book on her bed. It was The Double Helix, James Watson’s account of how he and Francis Crick had discovered the structure of DNA, the spiral-staircase molecule that carries the genetic instruction code for all forms of life. This book guided Jennifer Doudna to focus her studies not on DNA, but on what seemed to take a backseat in biochemistry: figuring out the structure of RNA, a closely related molecule that enables the genetic instructions coded in DNA to express themselves.

It can come in waves - like tidal waves. It changes societies. It disrupts life. It ends lives. As far back as 3000 B.C.E. (the Bronze Age), plagues have stricken mankind. COVID-19 is just the latest example, but history shows that life continues. It shows that knowledge and social cooperation can save lives. Viruses are neither alive nor dead and are the closest thing we have to zombies. Their only known function is to replicate themselves, which can have devastating consequences on their hosts.

With The Glass Ledge, Oubou offers a disruptive guide that explores the 10 most common themes around which women tend to derail themselves, including issues around power, likability, authenticity, conflict, and more. They are organized according to when we are most likely to face them head-on, as some issues present earlier in our careers while others tend to appear later. Each chapter focuses on one of these nuanced themes, incorporating counterintuitive and eye-opening information, including:

In this exciting true adventure mixed with amazing scientific study, a young, exuberant explorer and geoscientist journeys deep into the Amazon - where rivers boil and legends come to life. When Andrés Ruzo was just a small boy in Peru, his grandfather told him the story of a mysterious legend: There is a river, deep in the Amazon, that boils as if a fire burns below it. Twelve years later, Ruzo - now a geoscientist - hears his aunt mention that she herself had visited this strange river....

Vaccine reluctance and refusal are no longer limited to the margins of society. Debates around vaccines' necessity - along with questions around their side effects - have gone mainstream, blending with geopolitical conflicts, political campaigns, celebrity causes, and "natural" lifestyles to win a growing number of hearts and minds. Today's anti-vaccine positions find audiences where they've never existed previously.

The 19th century was an exciting time of initiative and enterprise around the world. If John D. Rockefeller was creating unimagined wealth in the United States that he would put to the service of the nation, a Parsi family with humble roots was doing the same in India. The Tatas is a tribute to a line of visionaries who have a special place in the hearts and minds of ordinary Indians. Written by seasoned journalist Girish Kuber, this is also the only book that tells the complete Tata story spanning almost 200 years.

The best-selling young adult novelist recounts her daughter's mysterious shooting death and her own investigation into the crime, describing her use of a psychic to contact her dead child and expose the truth.

Levitt and co-author Stephen J. Dubner show that economics is, at root, the study of incentives: how people get what they want, or need, especially when other people want or need the same thing. In Freakonomics, they explore the hidden side of...well, everything. The inner working of a crack gang...the truth about real-estate agents...the secrets of the Klu Klux Klan. What unites all these stories is a belief that the modern world is even more intriguing than we think. All it takes is a new way of looking, and Freakonomics will redefine the way we view the modern world.

Pandora's Lab takes us from opium's heyday as the pain reliever of choice to recognition of opioids as a major cause of death in the United States; from the rise of trans fats as the golden ingredient for tastier, cheaper food to the heart disease epidemic that followed; and from the cries to ban DDT for the sake of the environment to an epidemic-level rise in world malaria.

When Alex Stone was five years old, his father bought him a magic kit - a gift that would spark a lifelong love. Years later, while living in New York City, he discovered a vibrant underground magic scene exploding with creativity and innovation and populated by a fascinating cast of characters: from his gruff mentor, who holds court in the back of a rundown pizza shop, to one of the world's greatest card cheats, who also happens to be blind. Captivated, he plunged headlong into this mysterious world.

How does life work? How does nature produce the right numbers of zebras and lions on the African savanna, or fish in the ocean? How do our bodies produce the right numbers of cells in our organs and bloodstream? In The Serengeti Rules, award-winning biologist and author Sean B. Carroll tells the stories of the pioneering scientists who sought the answers to such simple yet profoundly important questions.

Brimming with fascinating historical details and modern medical wonders, this important audiobook is a fascinating glimpse into the struggles and "eureka!" moments that people outside of the medical profession rarely see. Written with Dr. Mukherjee's signature eloquence and passionate prose, The Laws of Medicine is a critical book not just for those in the medical profession but for everyone who is moved to better understand how their health and well-being are being treated.

Our brains are the most complex machines known to humankind, but they have an Achilles heel: The very molecules that allow us to exist can also sabotage our minds. Here are true accounts of unruly molecules and the diseases that form in their wake, from total loss of inhibitions to florid psychosis to compulsive lying.

When Elon Musk was a kid in South Africa, he was regularly beaten by bullies. One day a group pushed him down some concrete steps and kicked him until his face was a swollen ball of flesh. He was in the hospital for a week. But the physical scars were minor compared to the emotional ones inflicted by his father, an engineer, rogue, and charismatic fantasist.

From trips on private jets and encounters with world leaders to shocking accounts of misogyny and double standards behind the scenes, this searing memoir exposes both the personal and the political fallout when unfettered power and a rotten company culture take hold. In a gripping and often absurd narrative where a few people carelessly hold the world in their hands, this eye-opening memoir reveals what really goes on among the global elite.

Based on more than 40 interviews with Jobs conducted over two years—as well as interviews with more than a hundred family members, friends, adversaries, competitors, and colleagues—Walter Isaacson has written a riveting story of the roller-coaster life and searingly intense personality of a creative entrepreneur whose passion for perfection and ferocious drive revolutionized six industries: personal computers, animated movies, music, phones, tablet computing, and digital publishing.

Reporter Sam Kean reveals the periodic table as it’s never been seen before. Not only is it one of man's crowning scientific achievements, it's also a treasure trove of stories of passion, adventure, betrayal, and obsession. The infectious tales and astounding details in The Disappearing Spoon follow carbon, neon, silicon, and gold as they play out their parts in human history, finance, mythology, war, the arts, poison, and the lives of the (frequently) mad scientists who discovered them.

Everyone is programmed a little differently, and Bill Gates' unique insight led to business triumphs that are now widely known: the twenty-year-old who dropped out of Harvard to start a software company that became an industry giant and changed the way the world works and lives; the billionaire many times over who turned his attention to philanthropic pursuits to address climate change, global health, and U.S. education.

Why we think it’s a great listen: You thought he was a stodgy scientist with funny hair, but Isaacson and Hermann reveal an eloquent, intense, and selfless human being who not only shaped science with his theories, but politics and world events in the 20th century as well. Based on the newly released personal letters of Albert Einstein, Walter Isaacson explores how an imaginative, impertinent patent clerk became the mind reader of the creator of the cosmos.

In The Optimist, the Wall Street Journal reporter Keach Hagey presents the most detailed account yet of Altman’s rise, from his precocious childhood in St. Louis to his first, failed startup experience; his time as legendary entrepreneur Paul Graham’s protégé and successor as head of Y Combinator, the start-up accelerator where Altman became the premier power broker in Silicon Valley; the founding of OpenAI and his recruitment of a small yet superior team; and his struggle to keep his company at the cutting edge while fending off determined rivals, including Elon Musk.

When Michael Pollan set out to research how LSD and psilocybin (the active ingredient in magic mushrooms) are being used to provide relief to people suffering from difficult-to-treat conditions such as depression, addiction, and anxiety, he did not intend to write what is undoubtedly his most personal book. But upon discovering how these remarkable substances are improving the lives not only of the mentally ill but also of healthy people coming to grips with the challenges of everyday life, he decided to explore the landscape of the mind in the first person as well as the third.

J. Robert Oppenheimer was one of the iconic figures of the 20th century, a brilliant physicist who led the effort to build the atomic bomb but later confronted the moral consequences of scientific progress. When he proposed international controls over atomic materials, opposed the development of the hydrogen bomb, and criticized plans for a nuclear war, his ideas were anathema to powerful advocates of a massive nuclear buildup during the anti-Communist hysteria of the early 1950s.

The bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.

Following his blockbuster biography of Steve Jobs, The Innovators is Walter Isaacson’s revealing story of the people who created the computer and the Internet. It is destined to be the standard history of the digital revolution and an indispensable guide to how innovation really happens. What were the talents that allowed certain inventors and entrepreneurs to turn their visionary ideas into disruptive realities? What led to their creative leaps? Why did some succeed and others fail?

Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells - taken without her knowledge - became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than 60 years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects.

When Randy Pausch, a computer science professor at Carnegie Mellon, was asked to give such a lecture, he didn't have to imagine it as his last, since he had recently been diagnosed with terminal cancer. But the lecture he gave - "Really Achieving Your Childhood Dreams" - wasn't about dying. It was about the importance of overcoming obstacles, of enabling the dreams of others, of seizing every moment (because "time is all you have... and you may find one day that you have less than you think").

Astrophysicist Neil deGrasse Tyson has attracted one of the world’s largest online followings with his fascinating, widely accessible insights into science and our universe. Now, Tyson invites us to go behind the scenes of his public fame by unveiling his candid correspondence with people across the globe who have sought him out in search of answers. In this hand-picked collection of 100 letters, Tyson draws upon cosmic perspectives to address a vast array of questions about science, faith, philosophy, life, and of course, Pluto.

Suzanne Simard is a pioneer on the frontier of plant communication and intelligence; her TED talks have been viewed by more than 10 million people worldwide. In this, her first book, now available in audio, Simard brings us into her world, the intimate world of the trees, in which she brilliantly illuminates the fascinating and vital truths—that trees are not simply the source of timber or pulp, but are a complicated, interdependent circle of life.

From launchpad explosions to a pernicious cricket infestation to the demanding management style of Musk himself, the rise of SpaceX was beset with challenges and far from inevitable. Find out how the startup beat the odds and flew high enough to outpace their rivals... and where they're going next.

In Thunderstruck, Erik Larson tells the interwoven stories of two men: Hawley Crippen, a very unlikely murderer, and Guglielmo Marconi, the obsessive creator of a seemingly supernatural means of communication. Their lives intersect during one of the greatest criminal chases of all time.

From the New York Times bestselling author of Midnight in Chernobyl comes the definitive, dramatic, minute-by-minute story of the Challenger disaster, based on fascinating in-depth reporting and new archival research—a riveting history that flows like a thriller.

Bob Lazar was a brilliant young physicist that found himself employed at a top-secret facility in the middle of the desert outside Las Vegas. Under the watchful eye of the government elite, he is tasked with understanding an exotic propulsion system being used by an advanced aerospace vehicle he is told came from outer space. The stressful work and long, odd hours start to wear on Bob and he becomes concerned for his safety. He tells his wife and a couple close friends about what he's doing in the desert, and his employers find out and are furious.

Adam Savage is a maker. From Chewbacca’s bandolier to a 1,000-shot Nerf gun, he has built thousands of spectacular projects as a special-effects artist and the cohost of MythBusters. Adam is also an educator, passionate about instilling the principles of making in the next generation of inventors and inspiring them to turn their curiosity into creation. In this practical and passionate guide, Adam weaves together vivid personal stories, original sketches and photographs from some of his most memorable projects, and interviews with many of his iconic and visionary friends.

David Starr Jordan was a taxonomist, a man possessed with bringing order to the natural world. In time, he would be credited with discovering nearly a fifth of the fish known to humans in his day. When his specimen collections were demolished by lightning, by fire, and eventually by the 1906 San Francisco earthquake, many might have given up, given in to despair. But Jordan? He surveyed the wreckage at his feet, found the first fish that he recognized, and confidently began to rebuild his collection. And this time, he introduced one clever innovation.