Dirty Genes

1. Your genes are not your destiny: Lifestyle choices can "clean" dirty genes

"Your genes are not your destiny!"

Genetic potential. Your genes are not fixed instructions but dynamic participants in your daily health. They respond to your diet, environment, and lifestyle choices. "Dirty" genes can result from inherited variations (SNPs) or from poor lifestyle choices, leading to suboptimal function and various health issues.

Epigenetic influence. The field of epigenetics reveals that we can influence gene expression through our choices. By adopting healthy habits and avoiding harmful exposures, we can "clean" our genes, optimizing their function and improving our overall health. This understanding empowers individuals to take control of their genetic expression and potentially overcome inherited tendencies towards certain health conditions.

Key factors affecting gene function:

• Diet and nutrition
• Sleep quality and quantity
• Stress levels and management
• Environmental toxin exposure
• Physical activity
• Mental and emotional well-being

2. The Methylation Cycle: The key to optimal gene function and overall health

"Methylation controls your genetic expression. It determines whether a particular gene will be turned on—or off."

Biochemical foundation. The Methylation Cycle is a crucial biochemical process that affects over 200 functions in the body. It involves the transfer of methyl groups (one carbon and three hydrogen atoms) to various compounds, influencing genetic expression, neurotransmitter production, detoxification, and more.

Health implications. Proper methylation is essential for numerous aspects of health, including:

• DNA repair and cellular protection
• Neurotransmitter balance (affecting mood and cognition)
• Detoxification of harmful substances
• Hormone regulation
• Energy production
• Immune system function

Factors that can disrupt the Methylation Cycle include nutrient deficiencies (especially B vitamins), stress, toxin exposure, and certain genetic variations. Supporting this cycle through diet, lifestyle, and targeted supplementation can have far-reaching effects on overall health and well-being.

3. MTHFR: The master gene that initiates methylation and impacts numerous health conditions

"MTHFR is crucial to one of the body's most important biological processes—methylation."

Folate metabolism. The MTHFR gene produces an enzyme that converts folate (vitamin B9) into its active form, methylfolate. This active folate is essential for initiating the Methylation Cycle. Variations in MTHFR can affect this process, potentially leading to a wide range of health issues.

Health implications. MTHFR variations have been associated with:

• Cardiovascular disease
• Mental health disorders (depression, anxiety)
• Pregnancy complications and birth defects
• Certain cancers
• Chronic fatigue and fibromyalgia

Supporting MTHFR function involves:

• Consuming leafy green vegetables rich in natural folate
• Avoiding synthetic folic acid in supplements and fortified foods
• Ensuring adequate intake of other B vitamins, especially B12
• Managing stress and environmental toxin exposure

4. COMT: The gene that regulates stress hormones, mood, and focus

"COMT affects your production of catechols, estrogen, and some major neurotransmitters—dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline)."

Neurotransmitter balance. COMT regulates the levels of crucial neurotransmitters and hormones in the body. Variations in COMT can lead to either slow or fast processing of these compounds, affecting mood, stress response, and cognitive function.

Slow vs. Fast COMT:

• Slow COMT: Higher levels of dopamine and stress hormones
  • Pros: Better focus, productivity, and memory
  • Cons: Increased anxiety, difficulty relaxing
• Fast COMT: Lower levels of dopamine and stress hormones
  • Pros: Better stress resilience, easier to relax
  • Cons: Difficulty focusing, potential for addiction

Supporting COMT function involves tailoring diet and lifestyle to your specific variation:

• Slow COMT: Limit caffeine and stimulants, focus on stress reduction
• Fast COMT: Ensure adequate protein intake, engage in stimulating activities
• Both: Maintain magnesium levels, practice stress management techniques

5. DAO: The gene responsible for histamine processing and food sensitivities

"If your DAO is dirty, you're going to feel the effects of these chemicals sooner—long before you have the chance to get sick."

Histamine regulation. The DAO gene produces an enzyme that breaks down histamine in the gut. When DAO function is impaired, excess histamine can lead to various symptoms and food sensitivities.

Symptoms and support:

• Common symptoms of DAO dysfunction:
  • Digestive issues (bloating, diarrhea)
  • Headaches or migraines
  • Skin reactions (hives, itching)
  • Nasal congestion or runny nose
  • Anxiety or mood changes

Supporting DAO function:

• Limit high-histamine foods (aged cheeses, fermented foods, cured meats)
• Support gut health and reduce inflammation
• Consider DAO enzyme supplements with meals
• Ensure adequate copper and vitamin C intake

6. MAOA: The gene affecting mood stability and carbohydrate cravings

"MAOA affects your relationship to dopamine, norepinephrine, and serotonin, governing your mood, energy level, and ability to sleep, as well as sugar and carb cravings."

Neurotransmitter metabolism. MAOA regulates the breakdown of key neurotransmitters affecting mood, energy, and appetite. Variations can lead to either slow or fast processing of these compounds.

Slow vs. Fast MAOA:

• Slow MAOA: Higher levels of serotonin, dopamine, and norepinephrine
  • Pros: Potentially better mood and focus
  • Cons: Increased risk of aggression and impulsivity
• Fast MAOA: Lower levels of these neurotransmitters
  • Pros: Better stress resilience
  • Cons: Increased risk of depression and anxiety

Supporting MAOA function:

• Slow MAOA: Focus on stress reduction, limit tyramine-rich foods
• Fast MAOA: Ensure adequate protein intake, consider tryptophan-rich foods
• Both: Prioritize regular exercise, quality sleep, and stress management

7. GST/GPX: The genes crucial for detoxification and antioxidant protection

"You want to maximize the materials available to your Methylation Cycle, rather than shunting them off to make extra glutathione."

Cellular protection. GST and GPX genes are vital for producing glutathione, the body's master antioxidant. These genes play a crucial role in detoxifying harmful substances and protecting cells from oxidative stress.

Supporting GST/GPX function:

• Consume sulfur-rich foods (cruciferous vegetables, garlic, onions)
• Ensure adequate selenium intake (Brazil nuts, fish)
• Support overall detoxification through:
  • Regular exercise and sweating
  • Hydration with filtered water
  • Reducing exposure to environmental toxins
• Consider targeted supplements like N-acetylcysteine (NAC) or liposomal glutathione

8. NOS3: The gene influencing cardiovascular health and circulation

"NOS3 affects your production of nitric oxide, which is a major factor in heart health, affecting such processes as blood flow and blood vessel formation."

Vascular health. NOS3 is crucial for producing nitric oxide, a compound that helps dilate blood vessels, regulate blood pressure, and support overall cardiovascular health. Impaired NOS3 function can contribute to various circulatory and heart-related issues.

Supporting NOS3 function:

• Engage in regular aerobic exercise
• Consume nitrate-rich foods (beets, leafy greens)
• Ensure adequate intake of arginine and citrulline (found in watermelon, nuts, and seeds)
• Manage stress and practice deep breathing exercises
• Consider targeted supplements like L-arginine or beet root powder

9. PEMT: The gene supporting cell membranes, liver function, and pregnancy health

"PEMT affects your cell walls, brain, and liver, determining a wide range of health issues including pregnancy problems, gallstones, fatty liver, digestive problems, SIBO, attention problems, and menopause."

Phosphatidylcholine production. PEMT is responsible for producing phosphatidylcholine, a crucial component of cell membranes and a key player in liver function and fetal development. Impaired PEMT function can impact various aspects of health, particularly during pregnancy and menopause.

Supporting PEMT function:

• Ensure adequate choline intake (eggs, liver, lecithin)
• Support methylation through B-vitamin rich foods
• Consider phosphatidylcholine supplements, especially during pregnancy or for those with liver issues
• Maintain healthy estrogen levels through diet and lifestyle choices

10. The Clean Genes Protocol: A comprehensive approach to optimizing genetic function

"The Clean Genes Protocol is a program to optimize your health—and your life."

Holistic approach. The Clean Genes Protocol is a comprehensive lifestyle and dietary approach designed to support optimal gene function. It addresses multiple aspects of health to create an environment where genes can function at their best.

Key components of the Clean Genes Protocol:

1. Diet: Focus on whole, organic foods; avoid processed foods and common allergens
2. Sleep: Prioritize quality sleep and maintain consistent sleep-wake cycles
3. Exercise: Engage in regular, moderate exercise appropriate for your genetic profile
4. Stress management: Implement daily stress-reduction techniques
5. Toxin reduction: Minimize exposure to environmental toxins
6. Targeted supplementation: Address specific genetic needs with appropriate nutrients

The protocol is designed to be implemented in two phases:

• Soak and Scrub: A two-week period of general gene support
• Spot Cleaning: Tailored interventions for specific genetic variations

11. Personalized gene support: Tailoring your lifestyle to your unique genetic profile

"Understanding the combined impact of SNPs and lifestyle factors on our genetic function is where we need to be."

Individualized approach. While general healthy habits benefit everyone, understanding your specific genetic variations allows for a more targeted approach to optimizing health. This personalized strategy can lead to more effective interventions and better outcomes.

Steps for personalized gene support:

1. Identify your genetic variations through testing or symptom analysis
2. Understand the potential impacts of these variations on your health
3. Implement targeted dietary and lifestyle interventions
4. Monitor your response and adjust as needed
5. Work with healthcare professionals knowledgeable about genetic variations and functional medicine

Remember that genetic testing is just one piece of the puzzle. Your overall health status, lifestyle, and environment all play crucial roles in how your genes are expressed. The goal is to create an environment where your genes can function optimally, regardless of any inherited variations.

Last updated: January 25, 2025